![]() Comparison of the mRNAs predicted to regulate PTEN with recently published work, indicate that the results presented within the competing endogenous RNA database ( ceRDB) have biological relevance. By examining the co-occurrence of miRNA response elements in the mRNAs on a genome-wide basis we predict competing endogenous RNA for specific mRNAs targeted by miRNAs. in molecular and cell biology in 2003 from the Center for Cellular and Molecular Biology, Jawaharlal Nehru University, India, and completed his post-doctoral fellowship at Stanford. A genome-wide approach to comparative oncology: High-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. The institute seminar on Wednesday December 14th will be held by Subree Subramanian, Assistant Professor, Department of Surgery, University of Minnesota, Minneapolis, USA. The molecular basis of the mRNA-mRNA cross talks is via miRNA response elements, which can be predicted based on both molecular interaction and evolutionary conservation. Angstadt AY, Thayanithy V, Subramanian S, Modiano JF, and Breen M. The concept of regulation of a given mRNA by alternate mRNA (competing endogenous mRNA) by virtue of interactions with miRNAs through shared miRNA response elements is poised to become a fundamental genetic regulatory mechanism. University of Minnesota, Minneapolis, MN, USA e-mail: subree. ![]() ![]() Received JAccepted JPublished August 03, 2012Ī given mRNA can be regulated by interactions with miRNAs and in turn the availability of these miRNAs can be regulated by their interactions with alternate mRNAs. and Subbaya Subramanian Abstract The remarkable success of immunotherapy. ![]() Competing endogenous RNA database BACK TO CONTENTS |Īaron L Sarver 1 & Subbaya Subramanian 1, 2*ġMasonic Cancer Center 2Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MN *Corresponding author ![]()
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